Thursday, 14 February 2013

One That Slipped Under the Radar

Or something like that.
I held off talking about this abstract in the hope I might find some more material.

0918: Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS): No Evidence For Antibodies To Neuronal Surface Antigens
P Maddison, P Gozzard, T Jaspan. Nottingham University Hospitals NHS Trust, UK

This was a paper presented at the Association of British Neurologists Annual Meeting 2011. I was hoping in the mean-time a full-length follow-up paper might appear but no joy. I don't pretend to understand the detail of this abstract but what makes it interesting is it is one of the only bits of work I have seen which focuses specifically on possible mechanisms from analysis of tissue samples rather than patient studies. The key phrase is (I think) "we looked for evidence of antibodies to neuronal surface antigens that could be pathogenic, or act as biomarkers of CLIPPERS". Deconstructing this as best I can, the authors believe that CLIPPERS has an auto-immune component which presumably means that antibodies are involved somewhere or other. According to Wikipedia, antigens are things which "evoke the production of ... antibodies" and pathogens are things which cause disease. So in this work, experiments were performed to see if specific kinds of antibodies could be found which either were the cause of CLIPPERS and/or were characteristic of it so that their presence in tissue could be used as a test for CLIPPERS i.e. be a biomarker for CLIPPERS.

Unfortunately they didn't find anything but finish by saying: "It is possible that CLIPPERS could be mediated by other organ-specific antibodies to perivascular antigenic targets in the central nervous system, or alternatively a predominantly cell-mediated immune process.". So the jury is still out on this one.

In other news, my first clinic visit for a while is next week. Will report back as and when.

Read other articles in this series at Living With CLIPPERS.

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Living With CLIPPERS by Bill Crum is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.


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