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| Autumnal Shrooms |
Another CLIPPERS case study has appeared and the interesting thing about it (to my untrained eye) is that there seems to be nothing interesting about it. In fact, if there was a text-book about CLIPPERS, I would go as far as to say it is a text-book case.
In brief, the subject is a 51 year old man who suffered progressive ataxia, diplopia and weakness before being scanned and revealing the characteristic pattern of CLIPPERS-like lesions in the MR images. There is a lot more detail in the article, but essentially treatment was high-dose (1g/day) IV Prenisolone for 5 days followed by oral Prednisolone tapering down from 60mg/day and Azathioprine introduced in parallel to the tapering. This is basically the treatment I received, except I had a slower taper and a few stops and starts with the Azathioprine (because of blips in my blood-work).
This case is reassuring to see in the sense that many of the more recent case studies have either stretched the definition of CLIPPERS or have been complicated by CLIPPERS being diagnosed after, or alongside, other conditions. It is often difficult to get studies published when they are not sufficiently different to what has come before but, as the authors of this study say, "as a recently defined syndrome, any reported case is .... increasing the awareness of this disorder".
Read other articles in this series at Living With CLIPPERS.
Living With CLIPPERS by Bill Crum is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.
